Differences in cutaneous mast cells affect scar formation
نویسندگان
چکیده
منابع مشابه
Blockade of Mast Cell Activation Reduces Cutaneous Scar Formation
Damage to the skin initiates a cascade of well-orchestrated events that ultimately leads to repair of the wound. The inflammatory response is key to wound healing both through preventing infection and stimulating proliferation and remodeling of the skin. Mast cells within the tissue are one of the first immune cells to respond to trauma, and upon activation they release pro-inflammatory molecul...
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Scar formation is a potentially detrimental process of tissue restoration in adults, affecting organ form and function. During fetal development, cutaneous wounds heal without inflammation or scarring at early stages of development; however, they begin to heal with significant inflammation and scarring as the skin becomes more mature. One possible cell type that could regulate the change from s...
متن کاملMast Cells in Cutaneous Wound Healing
Mast cells are suggested to participate in wound healing, but their specific role has remained obscure. Mast cells are a rich source of inflammatory mediators, such as histamine, proteoglycans, the proteases tryptase and chymase, lipids, growth factors and cytokines. Among these mediators, there are many that have effects on cell growth, tissue turnover and repair. The aim of this study was to ...
متن کاملCutaneous wound healing: Significance of proteoglycans in scar formation
Proteoglycans (PGs), components of extracellular matrix (ECM), play an important role in modulating the structure and regulating the functions of the skin. The timely turnover of PGs influence the development and differentiation of cells. Wound healing also depends on the level of PGs which if not adequate leads to abnormal scars. The role of PGs in different phases of wound healing and their i...
متن کاملDensity of mast-cells and Microvessels Density in head and neck cutaneous Squamous Cell Carcinoma
Background and Aim: Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Mast cells may play a role in tumor progression and metastasis by increasing angiogenesis. The aim of this study was to investigate the role of mast cells by increasing angiogenesis in invasion of head and neck cutaneous squamous cell carcinoma. Materials and Methods: In this cross-sectional stud...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.565.17